Recipient antigen-processing pathways of allogeneic platelet antigens: essential mediators of immunitySEMPLE, John W; FREEDMAN, John.Transfusion (Philadelphia, PA). 2002, Vol 42, Num 7, pp 958-961, issn 0041-1132Article

The immunopathogenesis of immune thrombocytopenia: T cells still take center-stageSEMPLE, John W; PROVAN, Drew.Current opinion in hematology. 2012, Vol 19, Num 5, pp 357-362, issn 1065-6251, 6 p.Article

Autoimmune pathogenesis and autoimmune hemolytic anemiaSEMPLE, John W; FREEDMAN, John.Seminars in hematology. 2005, Vol 42, Num 3, pp 122-130, issn 0037-1963, 9 p.Article

Infections, Antigen-Presenting Cells, T Cells, and Immune Tolerance: Their Role in the Pathogenesis of Immune ThrombocytopeniaSEMPLE, John W.Hematology/oncology clinics of North America. 2009, Vol 23, Num 6, issn 0889-8588, 1177-1192, v [17 p.]Article

Plasma-derived biological medicines used to promote haemostasis : Current use of biologicals in thrombosis and haemostasisOFOSU, Frederick A; FREEDMAN, John; SEMPLE, John W et al.Thrombosis and haemostasis. 2008, Vol 99, Num 5, pp 851-862, issn 0340-6245, 12 p.Article

Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonistCOOPAMAH, Malini D; FREEDMAN, John; SEMPLE, John W et al.Blood. 2003, Vol 102, Num 8, pp 2862-2867, issn 0006-4971, 6 p.Article

White blood cell subsets in buffy coat-derived platelet concentrates : The effect of pre- and poststorage filtrationLEDENT, Elisabeth; SEMPLE, John W; BERLIN, Gösta et al.Vox sanguinis (Basel. 1956). 2000, Vol 79, Num 4, pp 235-241, issn 0042-9007Article

γ-Globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune responseSEMPLE, John W; KIM, Michael; LAZARUS, Alan H et al.Blood. 2002, Vol 100, Num 3, pp 1055-1059, issn 0006-4971Article

Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. CommentarySEMPLE, John W; STASI, Roberto; COOPER, Nichola et al.Blood. 2008, Vol 112, Num 4, issn 0006-4971, 927-928, 1147-1150 [6 p.]Article

Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopeniaLEYTIN, Valery; MYKHAYLOV, Sergiy; STARKEY, Alison F et al.British journal of haematology. 2006, Vol 133, Num 1, pp 78-82, issn 0007-1048, 5 p.Article

IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-γ response that is regulated by CD8⁺T cellsSAYEH, Ebrahim; STERLING, Katherine; SPECK, Edwin et al.Blood. 2004, Vol 103, Num 7, pp 2705-2709, issn 0006-4971, 5 p.Article

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injuryYOKE LIN FUNG; KIM, Michael; TABUCHI, Arata et al.Blood. 2010, Vol 116, Num 16, pp 3073-3079, issn 0006-4971, 7 p.Article

Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized plateletsSEMPLE, John W; ASLAM, Rukhsana; KIM, Michael et al.Blood. 2007, Vol 109, Num 11, pp 4803-4805, issn 0006-4971, 3 p.Article

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-a production in vivoASLAM, Rukhsana; SPECK, Edwin R; KIM, Michael et al.Blood. 2006, Vol 107, Num 2, pp 637-641, issn 0006-4971, 5 p.Article

Evaluation of Platelet Gel Characteristics Using Thrombin Produced by the Thrombin Processing Device : A Comparative StudySEMPLE, Elisabeth; SPECK, Edwin R; ASLAM, Rukhsana et al.Journal of oral and maxillofacial surgery. 2008, Vol 66, Num 4, pp 632-638, issn 0278-2391, 7 p.Article

Cellular immune dysfunction in immune thrombocytopenia (ITP)MCKENZIE, Christopher G. J; LI GUO; FREEDMAN, John et al.British journal of haematology. 2013, Vol 163, Num 1, pp 10-23, issn 0007-1048, 14 p.Article

Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine modelBRINC, Davor; LE-TIEN, Hoang; CROW, Andrew R et al.Transfusion (Philadelphia, PA). 2010, Vol 50, Num 9, pp 2016-2025, issn 0041-1132, 10 p.Article

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? CommentaryPSAILA, Bethan; BUSSEL, James B; CROW, Andrew R et al.Blood. 2007, Vol 109, Num 1, issn 0006-4971, 4-5,155-158 [6 p.]Article

Inhibition of xenogeneic GVHD by PEN 110 treatment of donor human PBMNCsFAST, Loren D; SEMPLE, John W; DILEONE, Gilbert et al.Transfusion (Philadelphia, PA). 2004, Vol 44, Num 2, pp 282-285, issn 0041-1132, 4 p.Article

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotypeSAYEH, Ebrahim; ASLAM, Rukshana; SPECK, Edwin R et al.Transfusion (Philadelphia, PA). 2004, Vol 44, Num 11, pp 1572-1578, issn 0041-1132, 7 p.Article

Leukoreduction just doesn't take away immunogenic leukcocytes, it creates an immunosuppressive leukocyte doseSEMPLE, John W; FREEDMAN, John.Vox sanguinis (Basel. 1956). 2002, Vol 83, pp 425-427, issn 0042-9007, 3 p., SUP1Conference Paper

A novel immunosuppressive pathway involving peroxynitrate-mediated nitration of platelet antigens within antigen-presenting cellsSEMPLE, John W; SPECK, Edwin R; FABRON, Antonio et al.Transfusion (Philadelphia, PA). 2008, Vol 48, Num 9, pp 1917-1924, issn 0041-1132, 8 p.Article

Recruitment of T cells into bone marrow of FTP patients possibly due to elevated expression of VLA-4 and CX3CR1. CommentarySEMPLE, John W; OLSSON, Bob; RIDELL, Börje et al.Blood. 2008, Vol 112, Num 4, issn 0006-4971, 927-928, 1078-1084 [9 p.]Article

Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cellsASLAM, Rukhsana; SPECK, Edwin R; KIM, Michael et al.Transfusion (Philadelphia, PA). 2008, Vol 48, Num 9, pp 1778-1786, issn 0041-1132, 9 p.Article

IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivityCROW, Andrew R; SENG SONG; SEMPLE, John W et al.British journal of haematology. 2001, Vol 115, Num 3, pp 679-686, issn 0007-1048Article